Projects

 

Basic SciencesClick to jump to section

 

TRANSLATIONAL RESEARCHClick to jump to section

 

CLINICAL RESEARCHClick to jump to section

 


Basic Sciences

Pain

Description: We employ a multidisciplinary approach — molecular, biochemical, in vitro and in vivo electrophysiological, behavioral — to evaluate mechanisms underlying pain and analgesia. Recent projects have emphasized understanding the transition from acute to chronic pain, neurotoxic effects of cancer chemotherapy and the use of hyaluronan in the treatment of pain.

Site: Parnassus

Contact: [email protected]

Faculty/Principal Investigator:

 

Jon Levine, MD, PhD

Translational Sciences

EpiBone Engineered Living Bone Graft for Mandibular Reconstruction

Description: Open label, first in human, interventional study for the evaluation of a bioengineered living bone graft for mandibular ramus reconstruction using autogenous lipoaspirate to derive mesenchymal stem cells.

Site: San Francisco VA Medical Center

Contact information: [email protected]

Faculty/Principal Investigator:


Rebeka Silva, DMD, FACD

Translational Sciences

Pain

Description: We employ a multidisciplinary approach — molecular, biochemical, in vitro and in vivo electrophysiological, behavioral — to evaluate mechanisms underlying pain and analgesia. Recent projects have emphasized understanding the transition from acute to chronic pain, neurotoxic effects of cancer chemotherapy and the use of hyaluronan in the treatment of pain.

Site: Parnassus

Contact: [email protected]

Faculty/Principal Investigator:

 

Jon Levine, MD, PhD

Dentoalveolar/Dental Implants

A Prospective Multi-Center Analysis of Factors Affecting Implant Success and Survival

Site: San Francisco VA Medical Center

Contact information: [email protected]

Faculty/Principal Investigator:


Shelley Miyasaki, DDS, PhD

Temporomandibular Disorders

Analysis of TMJ Surgery Outcomes, Complications

Description: Using information from hundreds of cases, an analysis of outcomes is being carried out to examine ways of mitigating complications related to TMJ surgery.

Site: San Francisco VA Medical Center

Contact information: [email protected]

Faculty/Principal Investigator:


Rebeka Silva, DMD, FACD

Surgical Education

Anesthesia Primer

Site: San Francisco VA Medical Center

Contact information: [email protected]

Faculty/Principal Investigator:


Shelley Miyasaki, DDS, PhD

Temporomandibular Disorders

Biomolecular Characterization of TMJ using single cell Transcriptomics and Advanced Microscopy

Description: Discarded TMJ specimens are analyzed to elucidate expression of multiple genes involved in inflammation and degeneration.

Site: San Francisco VA Medical Center

Contact information: [email protected]

Faculty/Principal Investigator:


Rebeka Silva, DMD, FACD

Benign Pathology, Temporomandibular Disorders

Calcium pyrophosphate deposition disease of the temporomandibular joint - diagnosis and treatment

Site: Highland Hospital

Contact information: [email protected]

Faculty/Principal Investigator:


Ricardo Lugo, DDS, MD

Akshay Govind, DMD, MD

Craniofaical Surgery, Sleep Surgery

Cephalometric Predictors of MMA success

Site: UCSF Medical Center

Contact information: [email protected]

Faculty/Principal Investigator:


Sampeter Odera, DMD, MD

Surgical Education

Complex Airway Management and Decision-Making in Maxillomandibular Fixation Crisis

Site: San Francisco VA Medical Center

Contact information: shelley.[email protected]

Faculty/Principal Investigator:


Shelley Miyasaki, DDS, PhD

Craniofacial Surgery

Complications of Subcranial LeFort III and Monobloc Distraction, with and without Facial Bipartition, using Rigid External Distractors

Description: Severe midface hypoplasia associated with syndromic craniosynostosis often requires midface advancement. There is a paucity of literature regarding the incidence of complications associated with midface and frontofacial advancement using rigid external distraction. A 10 year retrospective review was performed for patients with syndromic craniosynostosis who underwent subcranial Le Fort III or monobloc distraction with rigid external distraction, with and without facial bipartition, at Alder Hey Children’s Hospital in Liverpool, United Kingdom. A comprehensive review of the demographic information, operative and postoperative course was completed.

Site: Alder Hey Children’s Hospital NHS Trust

Contact information: [email protected]

Faculty/Principal Investigator:

 

Chris Parks, MBBS

Reconstruction

Delayed Alloplastic Total Joint Replacement for Osteoradionecrosis in Patients with Osseous Vascularized Free Flaps

Description: Case series of patients treated with an interval total joint replacement for osteoradionecrosis in the site of a previous osseous vascularized free flap. There is minimal literature demonstrating the effectiveness and success of alloplastic total joint replacements in conjunction with osseous vascularized free flaps. 

Site: Highland Hospital

Contact information: [email protected]

Faculty/Principal Investigator:


Ricardo Lugo, DDS, MD

Benign Pathology

Ectopic thyroid gland presenting in the submandibular gland

Description: The presentation of ectopic thyroid tissue along with a normal thryoid gland in the head and neck is not uncommon. This case report highlights a patient with an ectopic thyroid gland within the submandibular gland in addition to a lack of a normal thyroid gland. 

Site: Highland Hospital

Contact information: [email protected]

Faculty/Principal Investigator:


Ricardo Lugo, DDS, MD

Simulation/Medical Emergencies

Evaluating In-Office Emergency Prepardness in Oral & Maxillofacial Surgery Residents Using a Structured Clinical Simulation Curriculum

Description: Oral and maxillofacial surgeons safely perform thousands of in-office procedural sedations per year in the United States. One key aspect of performing safe in-office sedations is appropriate preparation for medical emergencies through clinical simulations. Using the simulation center at Highland Hospital, oral and maxillofacial surgery residents are guided through a structured curriculum with interval assessments of medical knowledge and skills assessments. 

Site: Highland Hospital

Contact information: [email protected]

Faculty/Principal Investigator:


Ricardo Lugo, DDS, MD

Maxillofacial Trauma

Evaluating Maxillofacial Surgeries incurred during Aquatic Sports

Site: UCSF Medical Center

Contact information: [email protected]

Faculty/Principal Investigator:


Brian Bast, DMD, MD

Craniofacial Surgery, Sleep Surgery 

Evaluation Outcomes of MMA Surgery

Site: San Francisco VA Medical Center

Contact information: [email protected]

Faculty/Principal Investigator:


Rishi Jay Gupta, DDS, MD, FACS

Maxillofacial Trauma

Facial Fractures and Hospital Admissions Associated with Olympic Event Associated Activities in the United States. 2010 – 2019

Site: UCSF Medical Center

Contact information: [email protected]

Resident:

Nisarg Patel, DMD


 

Craniofacial Surgery

Factors leading to Readmission Rates among orthognathic patients

Site: UCSF Medical Center

Contact information: [email protected]

Faculty/Principal Investigator:


Sampeter Odera, DMD, MD

Benign Pathology

Granular cell odontogenic tumor of the mandible

Description: Granular cell odontogenic tumor of the mandibule is a rare benign tumor occurring in the head and neck. This is a case report highlighting the diagnosis, histopathology, and treatment with en bloc resection and free tissue transfer. 

Site: Highland Hospital

Contact information: [email protected]

Faculty/Principal Investigator:


Ricardo Lugo, DDS, MD

Surgical Education

Hands-free method for two operators to hold full retraction in the posterior mandible

Site: Highland Hospital

Contact information: [email protected]

Faculty/Principal Investigator:


Akshay Govind, DMD, MD, MPH

Simulation/Medical Emergencies

Medical Emergency Simulation

Site: San Francisco VA Medical Center

Contact information: [email protected]

Faculty/Principal Investigator:


Shelley Miyasaki, DDS, PhD

Temporomandibular Disorders

Myofascial Pain

Site: San Francisco VA Medical Center

Contact information: [email protected]

Faculty/Principal Investigator:


Stephen Connelly, DDS, MD, PhD

Surgical Education

Office of Rural Health Pathway to Partnership – Oral Tele-Medicine

Site: San Francisco VA Medical Center

Contact information: [email protected]

Faculty/Principal Investigator:


Shelley Miyasaki, DDS, PhD

Malignant Pathology

Oral Cancer Histomorphometrics

Site: San Francisco VA Medical Center

Contact information: [email protected]

Faculty/Principal Investigator:


Stephen Connelly, DDS, MD, PhD

Craniofacial Surgery

Predicting and quantifying nasal changes after Le Fort I surgery

Site: UCSF Medical Center

Contact information: [email protected]

Faculty/Principal Investigator:


Sampeter Odera, DMD, MD

Malignant Pathology

Primary squamous cell carcinoma of the submandibular gland

Description: Squmaous cell carcinoma arising within the submandibular gland is an uncommon presentation within the field of head and neck. Although not rare, there is a paucity of contemporary literature that addresses the management of this disease with surgery and recent advancements in adjunctive treatment such as irradiation and chemotherapy. This case report aims centers around a patient who presents with locally advanced squamous cell carcinoma of the submandibular gland. 

Site: Highland Hospital

Contact information: [email protected]

Faculty/Principal Investigator:


Ricardo Lugo, DDS, MD

Neurosensory

Randomized controlled trial comparing neurosensory defecits using a Sonopet versus reciprocating saw in patients undergoing bilateral sagittal split osteotomies

Description: Split mouth, randomized controlled study comparing postoperative neurosensory deficits of the inferior alveolar nerve distribution when using a reciprocating saw versus a Sonopet for a bilateral sagittal split osteotomy. Patients will be randomized for laterality, type of saw used, and operating surgeon (resident or attending surgeon).

Site: UCSF Medical Center

Contact information: [email protected]

Faculty/Principal Investigator:

 

Sohail Saghezchi, DDS, MD

Dentoalveolar/Dental Implants

RCT Comparing Coronectomy Versus Surgical Extraction of High Risk Third Molars

Site: UCSF Medical Center

Contact information: [email protected]

Faculty/Principal Investigator:


Sampeter Odera, DMD, MD

Benign Pathology

RCT testing the Efficacy of 5FU, Vismodegib and Sonidegib, hedgehog inhibitors to reduce the recurrence of solitary mandbibular OKCs

Site: UCSF Medical Center

Contact information: [email protected]

Faculty/Principal Investigator:


Sampeter Odera, DMD, MD

Craniofacial Surgery

Stability of maxillomandibular complex counterclockwise rotation in orthognathic surgery

Description: In orthognathic surgery alterations of the occlusal plane by clockwise rotation (CWR) or counterclockwise rotation (CCWR) of the maxillomandibular complex allow for enhanced functional and esthetic results. Previous studies evaluating the post-operative stability of CCWR movement of the maxillomandibular complex showed relatively high rates of relapse. However, with improved rigid fixation and virtual surgical planning CCWR movements of the maxillomandibular complex is now thought to be more stable post-operatively, although there is a paucity of literature to support this. The aim of the study is to precisely evaluate the post-operative stability of counterclockwise rotational movement of the maxillomandibular complex utilizing three dimensional imaging and Mimics software.

Site: UCSF Medical Center, UCSF Mission Bay, Children’s Hospital Oakland

Contact information: [email protected]

Faculty/Principal Investigator:


Andrew Weeks, MD, DDS

Temporomandibular Disorders

Techniques for reducing the dislocated TMJ for the emergency room physician

Site: Highland Hospital

Contact information: [email protected]

Faculty/Principal Investigator:


Akshay Govind, DMD, MD, MPH

Temporomandibular Disorders

TMJ Imaging Techniques

Site: San Francisco VA Medical Center

Contact information: [email protected]

Faculty/Principal Investigator:


Stephen Connelly, DDS, MD, PhD

Surgical Education

Train the Trainer Program

Site: San Francisco VA Medical Center

Contact information: [email protected]

Faculty/Principal Investigator:


Shelley Miyasaki, DDS, PhD

Maxillofacial Trauma

Trends in Assault-Related Craniofacial Injuries Among Asians During the COVID-19

Description: Since the start of the COVID-19 pandemic, there has been an increase in racially motivated hate crimes involving physical violence towards the Asian American Pacific Islander (AAPI) community in the United States. This study aims to measure trends in assault-related craniofacial injuries among Asians during the COVID pandemic in San Francisco. We plan on conducting a retrospective cross-sectional study of assault-related craniofacial injuries in adults from November 17, 2018 (one year prior to the first case of COVID in China) to the present. Variables to be examined include date, sex, race, age, diagnosis, patient disposition, treatment, and prevalence of injuries from 2018 to the present.

Site: UCSF Medical Center

Contact information: [email protected]

Faculty/Principal Investigator:


Andrew Weeks, MD, DDS

Clinical Research

Trends in Work Relative Value Unit production in Oral and Maxillofacial Surgery

Site: UCSF Medical Center

Contact information: [email protected]

Faculty/Principal Investigator:


Sampeter Odera, DMD, MD

Craniofacial Surgery

Understanding the motivation, expectation and satisfaction of Orthognathic Patients – A Retrospective Review

Site: UCSF Medical Center

Contact information: [email protected]

Faculty/Principal Investigator:


Tony Pogrel, DDS, MD, FACS